Behavioral neuroBiology
NeuroTransmitters involved in drug seeking behavior
Decreased Dopamine in Nuclus Accubuns
Decreased Serotonin in Nuclus Accumbuns
Serotonic 1B receptors ---) less sensitive so tolerance develops slowly
Biology of Reinforcement
Brain Stimulus Reward (BSR) system (MFB&VTA)Dopamine in VTA and NA mechanisms
direct on dopamine as in case of Cocaine and stimulants as Amphetamins
Through Glutamate as in NMDA antagonists --)prevents potentiation or sensitization
Stimulation of M receptors in VTA and NA (local disinhibition effect on dopamine
through 5 HT1A
through GABA --) BDZ
Biology of Relapse
Conditioning Model ---)Stimuli can elicit withdrawal
Homeostatic Neuroadaptive model (protracted abstinence theory)
--)liking effect is different from wanting effed
repeated exposure causes sensitization to the wanting effects
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